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Aspartate decarboxylase (PanD) as a new target of pyrazinamide in Mycobacterium tuberculosis
Pyrazinamide (PZA) is a frontline anti-tuberculosis drug that plays a crucial role in the treatment of both drug-susceptible and multidrug-resistant tuberculosis (MDR-TB). PZA is a prodrug that is converted to its active form, pyrazinoic acid (POA), by a nicotinamidase/pyrazinamidase encoded by the...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4150287/ https://ncbi.nlm.nih.gov/pubmed/26038753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emi.2014.61 |
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