Aspartate decarboxylase (PanD) as a new target of pyrazinamide in Mycobacterium tuberculosis

Pyrazinamide (PZA) is a frontline anti-tuberculosis drug that plays a crucial role in the treatment of both drug-susceptible and multidrug-resistant tuberculosis (MDR-TB). PZA is a prodrug that is converted to its active form, pyrazinoic acid (POA), by a nicotinamidase/pyrazinamidase encoded by the...

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Main Authors: Shi, Wanliang, Chen, Jiazhen, Feng, Jie, Cui, Peng, Zhang, Shuo, Weng, Xinhua, Zhang, Wenhong, Zhang, Ying
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2014
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4150287/
https://ncbi.nlm.nih.gov/pubmed/26038753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emi.2014.61
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