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Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons

Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by the presence of intracellular aggregates of tau protein and neuronal loss leading to cognitive and motor impairment. Occurrence is mostly sporadic, but rare family clusters have been described. Although the etiopat...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Alquezar, Carolina, Felix, Jessica B., McCandlish, Elizabeth, Buckley, Brian T., Caparros-Lefebvre, Dominique, Karch, Celeste M., Golbe, Lawrence I., Kao, Aimee W.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969162/
https://ncbi.nlm.nih.gov/pubmed/31953414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56930-w
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