Allylated Curcumin Analog CA6 Inhibits TrxR1 and Leads to ROS-Dependent Apoptotic Cell Death in Gastric Cancer Through Akt-FoxO3a

BACKGROUND: Gastric cancer is one of the leading causes of cancer-related deaths. Allylated monocarbonyl analogs of curcumin (MACs) have been reported to selectively inhibit a broad range of human cancers including gastric cancer. However, the precise molecular mechanisms underlying the inhibitory a...

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Detalhes bibliográficos
Publicado no:Cancer Manag Res
Main Authors: Rajamanickam, Vinothkumar, Yan, Tao, Wu, Liangrong, Zhao, Yanni, Xu, Xiaohong, Zhu, Heping, Chen, Xi, Wang, Meihong, Liu, Zhoudi, Liu, Zhiguo, Liang, Guang, Wang, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2020
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6968823/
https://ncbi.nlm.nih.gov/pubmed/32021440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S227415
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