Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays

BACKGROUND: α-Synuclein is a small soluble protein, whose physiological function in the healthy brain is poorly understood. Intracellular inclusions of α-synuclein, referred to as Lewy bodies (LBs), are pathological hallmarks of α-synucleinopathies, such as Parkinson’s disease (PD) or dementia with...

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Detalles Bibliográficos
Publicado en:Transl Neurodegener
Main Authors: Candelise, Niccolo, Schmitz, Matthias, Thüne, Katrin, Cramm, Maria, Rabano, Alberto, Zafar, Saima, Stoops, Erik, Vanderstichele, Hugo, Villar-Pique, Anna, Llorens, Franc, Zerr, Inga
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
Assuntos:
Review
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966864/
https://ncbi.nlm.nih.gov/pubmed/31988747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-019-0181-9
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