Application of an in vitro-amplification assay as a novel pre-screening test for compounds inhibiting the aggregation of prion protein scrapie

In vitro amplification assays, such as real-time quaking-induced conversion (RT-QuIC) are used to detect aggregation activity of misfolded prion protein (PrP) in brain, cerebrospinal fluid (CSF) and urine samples from patients with a prion disease. We believe that the method also has a much broader...

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Publicat a:Sci Rep
Autors principals: Schmitz, Matthias, Cramm, Maria, Llorens, Franc, Candelise, Niccolò, Müller-Cramm, Dominik, Varges, Daniela, Schulz-Schaeffer, Walter J., Zafar, Saima, Zerr, Inga
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935936/
https://ncbi.nlm.nih.gov/pubmed/27385410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28711
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