Simultaneous Multi-Organ Metastases from Chemo-Resistant Triple-Negative Breast Cancer Are Prevented by Interfering with WNT-Signaling

Triple-negative breast cancers (TNBCs), which lack specific targeted therapy options, evolve into highly chemo-resistant tumors that metastasize to multiple organs simultaneously. We have previously shown that TNBCs maintain an activated WNT10B-driven network that drives metastasis. Pharmacologic in...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Fatima, Iram, El-Ayachi, Ikbale, Playa, Hilaire C., Alva-Ornelas, Jackelyn A., Khalid, Aysha B., Kuenzinger, William L., Wend, Peter, Pence, Jackelyn C., Brakefield, Lauren, Krutilina, Raisa I., Johnson, Daniel L., O’Regan, Ruth M., Seewaldt, Victoria, Seagroves, Tiffany N., Krum, Susan A., Miranda-Carboni, Gustavo A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966654/
https://ncbi.nlm.nih.gov/pubmed/31861131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11122039
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