Nanostructure of Clustered DNA Damage in Leukocytes after In-Solution Irradiation with the Alpha Emitter Ra-223

Background: Cancer patients are increasingly treated with alpha-particle-emitting radiopharmaceuticals. At the subcellular level, alpha particles induce densely spaced ionizations and molecular damage. Induction of DNA lesions, especially clustered DNA double-strand breaks (DSBs), threatens a cell’s...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Scherthan, Harry, Lee, Jin-Ho, Maus, Emanuel, Schumann, Sarah, Muhtadi, Razan, Chojowski, Robert, Port, Matthias, Lassmann, Michael, Bestvater, Felix, Hausmann, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966434/
https://ncbi.nlm.nih.gov/pubmed/31779276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11121877
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