The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change

In pharmacogenomic studies of quantitative change, any association between genetic variants and the pretreatment (baseline) measurement can bias the estimate of effect between those variants and drug response. A putative solution is to adjust for baseline. We conducted a series of genome-wide associ...

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Udgivet i:NPJ Genom Med
Main Authors: Oni-Orisan, Akinyemi, Haldar, Tanushree, Ranatunga, Dilrini K., Medina, Marisa W., Schaefer, Catherine, Krauss, Ronald M., Iribarren, Carlos, Risch, Neil, Hoffmann, Thomas J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965183/
https://ncbi.nlm.nih.gov/pubmed/31969989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41525-019-0109-4
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