Targeting Forward and Reverse EphB4/EFNB2 Signaling by a Peptide with Dual Functions

The tyrosine kinase receptor EphB4 is frequently overexpressed in ovarian and other solid tumors and is involved in interactions between tumor cells and the tumor microenvironment, contributing to metastasis. Trans-interaction between EphB4 and its membrane-bound ligand ephrin B2 (EFNB2) mediates bi...

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Udgivet i:Sci Rep
Main Authors: Xiong, Chiyi, Wen, Yunfei, Zhao, Jun, Yin, Dengke, Xu, Lingyun, Chelariu-Raicu, Anca, Yao, Cody, Leng, Xiaohong, Liu, Jinsong, Chaudhari, Rajan R., Zhang, Shuxing, Sood, Anil K., Li, Chun
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965176/
https://ncbi.nlm.nih.gov/pubmed/31949258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57477-x
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