Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients

Speciation is associated with substantial rewiring of the regulatory circuitry underlying the expression of genes. Determining which changes are relevant and underlie the emergence of the human brain or its unique susceptibility to neural disease has been challenging. Here we annotate changes to gen...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Castelijns, Bas, Baak, Mirna L., Timpanaro, Ilia S., Wiggers, Caroline R. M., Vermunt, Marit W., Shang, Peng, Kondova, Ivanela, Geeven, Geert, Bianchi, Valerio, de Laat, Wouter, Geijsen, Niels, Creyghton, Menno P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965079/
https://ncbi.nlm.nih.gov/pubmed/31949148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14269-w
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