Suppression of Superoxide-Hydrogen Peroxide Production at Site I(Q) of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes

Cardiogenic shock following cardiopulmonary resuscitation for sudden cardiac arrest is common, occurring even in the absence of acute coronary artery occlusion, and contributes to high rates of postcardiopulmonary resuscitation mortality. The pathophysiology of this shock is unclear, and effective t...

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Publicat a:Crit Care Med
Autors principals: Piao, Lin, Fang, Yong-Hu, Hamanaka, Robert B., Mutlu, Gökhan M., Dezfulian, Cameron, Archer, Stephen L., Sharp, Willard W.
Format: Artigo
Idioma:Inglês
Publicat: Lippincott Williams & Wilkins 2020
Matèries:
Online Laboratory Investigations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6964871/
https://ncbi.nlm.nih.gov/pubmed/31939812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000004095
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