HDAC5-mediated deacetylation and nuclear localisation of SOX9 is critical for tamoxifen resistance in breast cancer

BACKGROUND: Tamoxifen resistance remains a significant clinical challenge for the therapy of ER-positive breast cancer. It has been reported that the upregulation of transcription factor SOX9 in ER(+) recurrent cancer is sufficient for tamoxifen resistance. However, the mechanisms underlying the reg...

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Udgivet i:Br J Cancer
Main Authors: Xue, Yue, Lian, Wenwen, Zhi, Jiaqi, Yang, Wenjuan, Li, Qianjin, Guo, Xingyi, Gao, Jiahao, Qu, Hao, Lin, Weiqiang, Li, Zhongqi, Lai, Lihua, Wang, Qingqing
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6964674/
https://ncbi.nlm.nih.gov/pubmed/31690832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0625-0
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