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Insertion of Bacteriorhodopsin Helix C Variants into Biological Membranes

[Image: see text] A peptide corresponding to bacteriorhodopsin (bR) helix C, later named pHLIP, inserts across lipid bilayers as a monomeric α-helix at acidic pH, but is an unstructured surface-bound monomer at neutral pH. As a result of such pH-responsiveness, pHLIP targets acidic tumors and has be...

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Foilsithe in:ACS Omega
Main Authors: Bañó-Polo, Manuel, Martínez-Gil, Luis, Barrera, Francisco N., Mingarro, Ismael
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2019
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6964287/
https://ncbi.nlm.nih.gov/pubmed/31956802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b03126
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