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Re-Understanding the Mechanisms of Action of the Anti-Mycobacterial Drug Bedaquiline
Bedaquiline (BDQ) inhibits ATP generation in Mycobacterium tuberculosis by interfering with the F-ATP synthase activity. Two mechanisms of action of BDQ are broadly accepted. A direct mechanism involves BDQ binding to the enzyme’s c-ring to block its rotation, thus inhibiting ATP synthesis in the en...
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| Pubblicato in: | Antibiotics (Basel) |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
MDPI
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6963887/ https://ncbi.nlm.nih.gov/pubmed/31835707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antibiotics8040261 |
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