13-(2-Methylbenzyl) Berberine Is a More Potent Inhibitor of MexXY-Dependent Aminoglycoside Resistance than Berberine

We previously showed that berberine attenuates MexXY efflux-dependent aminoglycoside resistance in Pseudomonas aeruginosa. Here, we aimed to synthesize berberine derivatives with higher MexXY inhibitory activities. We synthesized 11 berberine derivatives, of which 13-(2-methylbenzyl) berberine (13-o...

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Detaylı Bibliyografya
Yayımlandı:Antibiotics (Basel)
Asıl Yazarlar: Kotani, Kenta, Matsumura, Mio, Morita, Yuji, Tomida, Junko, Kutsuna, Ryo, Nishino, Kunihiko, Yasuike, Shuji, Kawamura, Yoshiaki
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6963850/
https://ncbi.nlm.nih.gov/pubmed/31698691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antibiotics8040212
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