Genomic analyses of flow-sorted Hodgkin Reed-Sternberg cells reveal complementary mechanisms of immune evasion

Classical Hodgkin lymphoma (cHL) is composed of rare malignant Hodgkin Reed-Sternberg (HRS) cells within an extensive, but ineffective, inflammatory/immune cell infiltrate. HRS cells exhibit near-universal somatic copy gains of chromosome 9p/9p24.1, which increase expression of the programmed cell d...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Wienand, Kirsty, Chapuy, Bjoern, Stewart, Chip, Dunford, Andrew J., Wu, David, Kim, Jaegil, Kamburov, Atanas, Wood, Timothy R., Cader, Fathima Zumla, Ducar, Matthew D., Thorner, Aaron R., Nag, Anwesha, Heubeck, Alexander T., Buonopane, Michael J., Redd, Robert A., Bojarczuk, Kamil, Lawton, Lee N., Armand, Philippe, Rodig, Scott J., Fromm, Jonathan R., Getz, Gad, Shipp, Margaret A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6963251/
https://ncbi.nlm.nih.gov/pubmed/31816062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019001012
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