Oral Bruton tyrosine kinase inhibitors block activation of the platelet Fc receptor CD32a (FcγRIIA): a new option in HIT?

Activation of the platelet Fc-receptor CD32a (FcγRIIA) is an early and crucial step in the pathogenesis of heparin-induced thrombocytopenia type II (HIT) that has not been therapeutically targeted. Downstream FcγRIIA Bruton tyrosine kinase (BTK) is activated; however, its role in Fc receptor–induced...

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Bibliografische gegevens
Gepubliceerd in:Blood Adv
Hoofdauteurs: Goldmann, Luise, Duan, Rundan, Kragh, Thorsten, Wittmann, Georg, Weber, Christian, Lorenz, Reinhard, von Hundelshausen, Philipp, Spannagl, Michael, Siess, Wolfgang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2019
Onderwerpen:
Thrombosis and Hemostasis
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6963242/
https://ncbi.nlm.nih.gov/pubmed/31809536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000617
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