Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds

There is significant interest in the potential utility of small-molecule activator compounds to mitigate cardiac arrhythmia caused by loss of function of hERG1a voltage-gated potassium channels. Zebrafish (Danio rerio) have been proposed as a cost-effective, high-throughput drug-screening model to i...

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Pubblicato in:Am J Physiol Regul Integr Comp Physiol
Autori principali: Hull, Christina M., Genge, Christine E., Hobbs, Yuki, Rayani, Kaveh, Lin, Eric, Gunawan, Marvin, Shafaattalab, Sanam, Tibbits, Glen F., Claydon, Tom W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962622/
https://ncbi.nlm.nih.gov/pubmed/31664867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00190.2019
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