Lung genotoxicity of benzo(a)pyrene in vivo involves reactivation of LINE-1 retrotransposon and early reprogramming of oncogenic regulatory networks

Several lines of evidence have implicated long interspersed nuclear element-1 (LINE-1) retroelement in the onset and progression of lung cancer. Retrotransposition-dependent mechanisms leading to DNA mobilization give rise to insertion mutations and DNA deletions, whereas retrotransposition-independ...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Am J Physiol Lung Cell Mol Physiol
Päätekijät: Hassanin, A. A. I., Tavera-Garcia, M., Moorthy, B., Zhou, G. D., Ramos, K. S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Physiological Society 2019
Aiheet:
Rapid Report
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962597/
https://ncbi.nlm.nih.gov/pubmed/31596105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00304.2019
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