RTD-1 therapeutically normalizes synovial gene signatures in rat autoimmune arthritis and suppresses proinflammatory mediators in RA synovial fibroblasts

Rhesus theta defensin-1 (RTD-1), a macrocyclic immunomodulatory host defense peptide from Old World monkeys, is therapeutic in pristane-induced arthritis (PIA) in rats, a model of rheumatoid arthritis (RA). RNA-sequence (RNA-Seq) analysis was used to interrogate the changes in gene expression in PIA...

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Enregistré dans:
Détails bibliographiques
Publié dans:Physiol Genomics
Auteurs principaux: Tongaonkar, Prasad, Punj, Vasu, Subramanian, Akshay, Tran, Dat Q., Trinh, Katie K., Schaal, Justin B., Laragione, Teresina, Ouellette, André J., Gulko, Percio S., Selsted, Michael E.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962595/
https://ncbi.nlm.nih.gov/pubmed/31762409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00066.2019
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