Scaffold stiffness influences breast cancer cell invasion via EGFR-linked Mena upregulation and matrix remodeling

Clinically, increased breast tumor stiffness is associated with metastasis and poorer outcomes. Yet, in vitro studies of tumor cells in 3D scaffolds have found decreased invasion in stiffer environments. To resolve this apparent contradiction, MDA-MB-231 breast tumor spheroids were embedded in ‘low’...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Matrix Biol
Egile Nagusiak: Berger, Anthony J., Renner, Carine M., Hale, Isaac, Yang, Xinhai, Ponik, Suzanne M., Weisman, Paul S., Masters, Kristyn S., Kreeger, Pamela K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962577/
https://ncbi.nlm.nih.gov/pubmed/31323325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2019.07.006
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