Scaffold stiffness influences breast cancer cell invasion via EGFR-linked Mena upregulation and matrix remodeling

Clinically, increased breast tumor stiffness is associated with metastasis and poorer outcomes. Yet, in vitro studies of tumor cells in 3D scaffolds have found decreased invasion in stiffer environments. To resolve this apparent contradiction, MDA-MB-231 breast tumor spheroids were embedded in ‘low’...

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Dettagli Bibliografici
Pubblicato in:Matrix Biol
Autori principali: Berger, Anthony J., Renner, Carine M., Hale, Isaac, Yang, Xinhai, Ponik, Suzanne M., Weisman, Paul S., Masters, Kristyn S., Kreeger, Pamela K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962577/
https://ncbi.nlm.nih.gov/pubmed/31323325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2019.07.006
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