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Targeting the tumor vasculature with engineered cystine-knot miniproteins
The extra domain B splice variant (EDB) of human fibronectin selectively expressed in the tumor vasculature is an attractive target for cancer imaging and therapy. Here, we describe the generation and characterization of EDB-specific optical imaging probes. By screening combinatorial cystine-knot mi...
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| Publicat a: | Nat Commun |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6962393/ https://ncbi.nlm.nih.gov/pubmed/31941901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13948-y |
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