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Combination of Olanzapine and Samidorphan Has No Clinically Significant Effect on the Pharmacokinetics of Lithium or Valproate

BACKGROUND AND OBJECTIVE: Olanzapine is an atypical antipsychotic indicated for the treatment of schizophrenia and, either as monotherapy or as an adjunct to lithium or valproate, for bipolar I disorder. Multiple daily doses of olanzapine do not affect the pharmacokinetics of lithium or valproate; t...

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Bibliographic Details
Published in:Clin Drug Investig
Main Authors: Sun, Lei, Yagoda, Sergey, Yao, Baiyun, Graham, Christine, von Moltke, Lisa
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962313/
https://ncbi.nlm.nih.gov/pubmed/31584140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40261-019-00860-y
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