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Effect of hepatic and renal impairment on the pharmacokinetics of olanzapine and samidorphan given in combination as a bilayer tablet
BACKGROUND: A combination of olanzapine and samidorphan (OLZ/SAM) is in development to provide the established antipsychotic efficacy of olanzapine while mitigating olanzapine-induced weight gain. METHODS: Two multicenter, open-label, parallel-cohort studies were performed to evaluate the effect of...
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| Vydáno v: | Drug Des Devel Ther |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Dove
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6709789/ https://ncbi.nlm.nih.gov/pubmed/31686778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S205000 |
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