Mitophagy-dependent macrophage reprogramming protects against kidney fibrosis

Mitophagy, by maintaining mitochondrial quality control, plays a key role in maintaining kidney function and is impaired in pathologic states. Macrophages are well known for their pathogenic role in kidney fibrosis. Here, we report that PINK1/Parkin-mediated mitophagy in macrophages is compromised i...

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Udgivet i:JCI Insight
Main Authors: Bhatia, Divya, Chung, Kuei-Pin, Nakahira, Kiichi, Patino, Edwin, Rice, Michelle C., Torres, Lisa K., Muthukumar, Thangamani, Choi, Augustine M.K., Akchurin, Oleh M., Choi, Mary E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962025/
https://ncbi.nlm.nih.gov/pubmed/31639106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.132826
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