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Mitophagy-dependent macrophage reprogramming protects against kidney fibrosis
Mitophagy, by maintaining mitochondrial quality control, plays a key role in maintaining kidney function and is impaired in pathologic states. Macrophages are well known for their pathogenic role in kidney fibrosis. Here, we report that PINK1/Parkin-mediated mitophagy in macrophages is compromised i...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | JCI Insight |
|---|---|
| Κύριοι συγγραφείς: | , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society for Clinical Investigation
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6962025/ https://ncbi.nlm.nih.gov/pubmed/31639106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.132826 |
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