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FGF23 expression is stimulated in transgenic α-Klotho longevity mouse model

Observations in transgenic α-Klotho (Kl) mice (Kl(Tg)) defined the antiaging role of soluble Klotho (sKL(130)). A genetic translocation that elevates sKL levels in humans is paradoxically associated with increased circulating fibroblast growth factor 23 (FGF23) levels and the potential of both membr...

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Podrobná bibliografie
Vydáno v:JCI Insight
Hlavní autoři: Xiao, Zhousheng, King, Gwendalyn, Mancarella, Salvatore, Munkhsaikhan, Undral, Cao, Li, Cai, Chun, Quarles, Leigh Darryl
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962016/
https://ncbi.nlm.nih.gov/pubmed/31801907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.132820
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