Liganded T3 receptor β2 inhibits the positive feedback autoregulation of the gene for GATA2, a transcription factor critical for thyrotropin production

The serum concentration of thyrotropin (thyroid stimulating hormone, TSH) is drastically reduced by small increase in the levels of thyroid hormones (T3 and its prohormone, T4); however, the mechanism underlying this relationship is unknown. TSH consists of the chorionic gonadotropin α (CGA) and the...

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Udgivet i:PLoS One
Main Authors: Hirahara, Naoko, Nakamura, Hiroko Misawa, Sasaki, Shigekazu, Matsushita, Akio, Ohba, Kenji, Kuroda, Go, Sakai, Yuki, Shinkai, Shinsuke, Haeno, Hiroshi, Nishio, Takuhiro, Yoshida, Shuichi, Oki, Yutaka, Suda, Takafumi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961892/
https://ncbi.nlm.nih.gov/pubmed/31940421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227646
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