Quality Control Strategy for CRISPR-Cas9-Based Gene Editing Complicated by a Pseudogene

CRISPR-Cas9 mediated gene editing in induced pluripotent stem cells became an efficient tool to investigate biological mechanisms underlying genetic-driven diseases while accounting for the respective genetic background. This technique relies on the targeting of a specific nucleotide sequence presen...

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Bibliographic Details
Published in:Front Genet
Main Authors: Hanss, Zoé, Boussaad, Ibrahim, Jarazo, Javier, Schwamborn, Jens C., Krüger, Rejko
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Genetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961559/
https://ncbi.nlm.nih.gov/pubmed/31998363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.01297
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