A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function

Type 2 diabetes (T2D) is a global pandemic with a strong genetic component, but most causal genes influencing the disease risk remain unknown. It is clear, however, that the pancreatic beta cell is central to T2D pathogenesis. In vitro gene-knockout (KO) models to study T2D risk genes have so far fo...

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Publicat a:Wellcome Open Res
Autors principals: Grotz, Antje K., Abaitua, Fernando, Navarro-Guerrero, Elena, Hastoy, Benoit, Ebner, Daniel, Gloyn, Anna L.
Format: Artigo
Idioma:Inglês
Publicat: F1000 Research Limited 2020
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Method Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961417/
https://ncbi.nlm.nih.gov/pubmed/31976379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/wellcomeopenres.15447.2
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