Efficacy of Ronopterin (VAS203) in Patients with Moderate and Severe Traumatic Brain Injury (NOSTRA phase III trial): study protocol of a confirmatory, placebo-controlled, randomised, double blind, multi-centre study

BACKGROUND: Traumatic brain injury is a leading cause of death and disability worldwide. The nitric oxide synthase inhibitor Ronopterin was shown to improve clinical outcome by enhancing neuroprotection in a phase IIa trial. METHODS/DESIGN: The NOSTRA phase III trial (Ronopterin in traumatic brain i...

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Bibliographic Details
Published in:Trials
Main Authors: Tegtmeier, Frank, Schinzel, Reinhard, Beer, Ronny, Bulters, Diederik, LeFrant, Jean-Yves, Sahuquillo, Joan, Unterberg, Andreas, Andrews, Peter, Belli, Antonio, Ibanez, Javier, Lagares, Alfonso, Mokry, Michael, Willschke, Harald, Flühe, Charlotte, Schmutzhard, Erich
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
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Study Protocol
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961322/
https://ncbi.nlm.nih.gov/pubmed/31937347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-019-3965-4
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