Co-activation of selective nicotinic acetylcholine receptors is required to reverse beta amyloid-induced Ca(2+) hyperexcitation

Beta-amyloid (Aβ) peptide accumulation has long been implicated in the pathogenesis of Alzheimer’s disease (AD). Hippocampal network hyperexcitability in the early stages of the disease leads to increased epileptiform activity and eventually cognitive decline. We found that acute application of 250n...

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Veröffentlicht in:Neurobiol Aging
Hauptverfasser: Sun, Julianna L., Stokoe, Sarah A., Roberts, Jessica P., Sathler, Matheus F., Nip, Kaila A., Shou, Jiayi, Ko, Kaitlyn, Tsunoda, Susan, Kim, Seonil
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6960326/
https://ncbi.nlm.nih.gov/pubmed/31629115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2019.09.005
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