Rescue of Amyloid-Beta-Induced Inhibition of Nicotinic Acetylcholine Receptors by a Peptide Homologous to the Nicotine Binding Domain of the Alpha 7 Subtype

Alzheimer's disease (AD) is characterized by brain accumulation of the neurotoxic amyloid-β peptide (Aβ) and by loss of cholinergic neurons and nicotinic acetylcholine receptors (nAChRs). Recent evidence indicates that memory loss and cognitive decline in AD correlate better with the amount of...

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Detalhes bibliográficos
Main Authors: Nery, Arthur A., Magdesian, Margaret H., Trujillo, Cleber A., Sathler, Luciana B., Juliano, Maria A., Juliano, Luiz, Ulrich, Henning, Ferreira, Sergio T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718777/
https://ncbi.nlm.nih.gov/pubmed/23894286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067194
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