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RPEL family rhoGAPs link Rac/Cdc42 GTP loading to G-actin availability
RPEL proteins, which contain the G-actin binding RPEL motif, coordinate cytoskeletal processes with actin dynamics. We show that the ArhGAP12- and ArhGAP32-family GTPase activating proteins are RPEL proteins. We determine the structure of the ArhGAP12/G-actin complex, and show that G-actin contacts...
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| Veröffentlicht in: | Nat Cell Biol |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6960015/ https://ncbi.nlm.nih.gov/pubmed/31209295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0337-y |
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