Acute cerebellar knockdown of Sgce reproduces salient features of myoclonus-dystonia (DYT11) in mice

Myoclonus dystonia (DYT11) is a movement disorder caused by loss-of-function mutations in SGCE and characterized by involuntary jerking and dystonia that frequently improve after drinking alcohol. Existing transgenic mouse models of DYT11 exhibit only mild motor symptoms, possibly due to rodent-spec...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:eLife
Asıl Yazarlar: Washburn, Samantha, Fremont, Rachel, Moreno-Escobar, Maria Camila, Angueyra, Chantal, Khodakhah, Kamran
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2019
Konular:
Neuroscience
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959989/
https://ncbi.nlm.nih.gov/pubmed/31868164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52101
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