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Acute cerebellar knockdown of Sgce reproduces salient features of myoclonus-dystonia (DYT11) in mice

Myoclonus dystonia (DYT11) is a movement disorder caused by loss-of-function mutations in SGCE and characterized by involuntary jerking and dystonia that frequently improve after drinking alcohol. Existing transgenic mouse models of DYT11 exhibit only mild motor symptoms, possibly due to rodent-spec...

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Bibliographische Detailangaben
Veröffentlicht in:eLife
Hauptverfasser: Washburn, Samantha, Fremont, Rachel, Moreno-Escobar, Maria Camila, Angueyra, Chantal, Khodakhah, Kamran
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959989/
https://ncbi.nlm.nih.gov/pubmed/31868164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52101
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