Calcium dobesilate reduces VEGF signaling by interfering with heparan sulfate binding site and protects from vascular complications in diabetic mice

Inhibiting vascular endothelial growth factor (VEGF) is a therapeutic option in diabetic microangiopathy. However, VEGF is needed at physiological concentrations to maintain glomerular integrity; complete VEGF blockade has deleterious effects on glomerular structure and function. Anti-VEGF therapy i...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Njau, Florence, Shushakova, Nelli, Schenk, Heiko, Wulfmeyer, Vera Christine, Bollin, Robin, Menne, Jan, Haller, Hermann
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2020
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959593/
https://ncbi.nlm.nih.gov/pubmed/31935212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0218494
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