Novel Radiolabeled Vanilloid with Enhanced Specificity for Human Transient Receptor Potential Vanilloid 1 (TRPV1)

Transient receptor potential vanilloid 1 (TRPV1) has emerged as a promising therapeutic target. While radiolabeled resiniferatoxin (RTX) has provided a powerful tool for characterization of vanilloid binding to TRPV1, TRPV1 shows 20-fold weaker binding to the human TRPV1 than to the rodent TRPV1. We...

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Udgivet i:J Med Chem
Main Authors: Pearce, Larry V., Ann, Jihyae, Jung, Aeran, Thorat, Shivaji A., Herold, Brienna K. A., Habtemichael, Amelework D., Blumberg, Peter M., Lee, Jeewoo
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959550/
https://ncbi.nlm.nih.gov/pubmed/28892388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00859
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