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Expression, Purification, and Characterization of Engineered Antibody CH2 and VH Domains

Most of the FDA-approved therapeutic monoclonal antibodies are full-size IgG molecules with a molecular weight of about 150 kDa. A major problem for such large molecules is their poor penetration into tissues (e.g., solid tumors) and poor or absent binding to regions on the surface of some molecules...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Methods Mol Biol
Hauptverfasser: Gong, Rui, Chen, Weizao, Dimitrov, Dimiter S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959533/
https://ncbi.nlm.nih.gov/pubmed/22735948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-61779-921-1_6
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