Preclinical evaluation of an affinity-enhanced MAGE-A4-specific T-cell receptor for adoptive T-cell therapy

A substantial obstacle to the success of adoptive T cell-based cancer immunotherapy is the sub-optimal affinity of T-cell receptors (TCRs) for most tumor antigens. Genetically engineered TCRs that have enhanced affinity for specific tumor peptide-MHC complexes may overcome this barrier. However, thi...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Sanderson, Joseph P, Crowley, Darragh J, Wiedermann, Guy E, Quinn, Laura L, Crossland, Katherine L, Tunbridge, Helen M, Cornforth, Terri V, Barnes, Christopher S, Ahmed, Tina, Howe, Karen, Saini, Manoj, Abbott, Rachel J, Anderson, Victoria E, Tavano, Barbara, Maroto, Miguel, Gerry, Andrew B
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959444/
https://ncbi.nlm.nih.gov/pubmed/32002290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2019.1682381
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