Differential Activation of TRPA1 by Diesel Exhaust Particles: Relationships between Chemical Composition, Potency, and Lung Toxicity

[Image: see text] Diesel exhaust particulate (DEP) causes pulmonary irritation and inflammation, which can exacerbate asthma and other diseases. These effects may arise from the activation of transient receptor potential ankyrin-1 (TRPA1). This study shows that a representative DEP can activate TRPA...

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發表在:Chem Res Toxicol
Main Authors: Deering-Rice, Cassandra E., Memon, Tosifa, Lu, Zhenyu, Romero, Erin G., Cox, James, Taylor-Clark, Thomas, Veranth, John M., Reilly, Christopher A.
格式: Artigo
語言:Inglês
出版: American Chemical Society 2019
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959364/
https://ncbi.nlm.nih.gov/pubmed/30945539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.8b00375
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