Haspin-dependent and independent effects of the kinase inhibitor 5-Iodotubercidin on self-renewal and differentiation

The kinase Haspin phosphorylates histone H3 at threonine-3 (H3T3ph), creating a docking site for the Chromosomal Passenger Complex (CPC). CPC plays a pivotal role in preventing chromosome misalignment. Here, we have examined the effects of 5-Iodotubercidin (5-ITu), a commonly used Haspin inhibitor,...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Karanika, Eleftheria, Soupsana, Katerina, Christogianni, Anastasia, Stellas, Dimitris, Klinakis, Apostolos, Politou, Anastasia S., Georgatos, Spyros
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959359/
https://ncbi.nlm.nih.gov/pubmed/31937797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54350-4
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