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Association of glomerular DNA damage and DNA methylation with one-year eGFR decline in IgA nephropathy

Accumulation of DNA double-strand breaks (DSBs) is linked to aging and age-related diseases. We recently reported the possible association of DNA DSBs with altered DNA methylation in murine models of kidney disease. However, DSBs and DNA methylation in human kidneys was not adequately investigated....

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hayashi, Kaori, Hishikawa, Akihito, Hashiguchi, Akinori, Azegami, Tatsuhiko, Yoshimoto, Norifumi, Nakamichi, Ran, Tokuyama, Hirobumi, Itoh, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959244/
https://ncbi.nlm.nih.gov/pubmed/31937846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-57140-0
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