Somatic variants in epigenetic modifiers can predict failure of response to imatinib but not to second-generation tyrosine kinase inhibitors

There are no validated molecular biomarkers to identify newly-diagnosed individuals with chronic-phase chronic myeloid leukemia likely to respond poorly to imatinib and who might benefit from first-line treatment with a more potent second-generation tyrosine kinase inhibitor. Our inability to predic...

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Veröffentlicht in:Haematologica
Hauptverfasser: Nteliopoulos, Georgios, Bazeos, Alexandra, Claudiani, Simone, Gerrard, Gareth, Curry, Edward, Szydlo, Richard, Alikian, Mary, Foong, Hui En, Nikolakopoulou, Zacharoula, Loaiza, Sandra, Khorashad, Jamshid S., Milojkovic, Dragana, Perrotti, Danilo, Gale, Robert Peter, Foroni, Letizia, Apperley, Jane F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959189/
https://ncbi.nlm.nih.gov/pubmed/31073075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.200220
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