OCIAD1 contributes to neurodegeneration in Alzheimer's disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages

BACKGROUND: Hyperamyloidosis in the brain is known as the earliest neuropathological change and a unique etiological factor in Alzheimer's disease (AD), while progressive neurodegeneration in certain vulnerable brain regions forms the basis of clinical syndromes. It is not clear how early hyper...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Li, Xuping, Wang, Lin, Cykowski, Matthew, He, Tiancheng, Liu, Timothy, Chakranarayan, Joshua, Rivera, Andreana, Zhao, Hong, Powell, Suzanne, Xia, Weiming, Wong, Stephen T.C.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957876/
https://ncbi.nlm.nih.gov/pubmed/31931285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.11.030
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