CD44 contributes to hyaluronan-mediated insulin resistance in skeletal muscle of high-fat-fed C57BL/6 mice

Extracellular matrix hyaluronan is increased in skeletal muscle of high-fat-fed insulin-resistant mice, and reduction of hyaluronan by PEGPH20 hyaluronidase ameliorates diet-induced insulin resistance (IR). CD44, the main hyaluronan receptor, is positively correlated with type 2 diabetes. This study...

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Vydáno v:Am J Physiol Endocrinol Metab
Hlavní autoři: Hasib, Annie, Hennayake, Chandani K., Bracy, Deanna P., Bugler-Lamb, Aimée R., Lantier, Louise, Khan, Faisel, Ashford, Michael L. J., McCrimmon, Rory J., Wasserman, David H., Kang, Li
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957377/
https://ncbi.nlm.nih.gov/pubmed/31550181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00215.2019
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