A multi-state model of the CaMKII dodecamer suggests a role for calmodulin in maintenance of autophosphorylation

Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) accounts for up to 2 percent of all brain protein and is essential to memory function. CaMKII activity is known to regulate dynamic shifts in the size and signaling strength of neuronal connections, a process known as synaptic plasticity. Increa...

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Publicat a:PLoS Comput Biol
Autors principals: Pharris, Matthew C., Patel, Neal M., VanDyk, Tyler G., Bartol, Thomas M., Sejnowski, Terrence J., Kennedy, Mary B., Stefan, Melanie I., Kinzer-Ursem, Tamara L.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957207/
https://ncbi.nlm.nih.gov/pubmed/31869343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006941
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