Discovery of VU6015929: A Selective Discoidin Domain Receptor 1/2 (DDR1/2) Inhibitor to Explore the Role of DDR1 in Antifibrotic Therapy

[Image: see text] Herein, we report the discovery of a potent and selective dual DDR1/2 inhibitor, 7e (VU6015929), displaying low cytotoxicity, good kinome selectivity, and possessing an acceptable in vitro DMPK profile with good rodent in vivo pharmacokinetics. VU6015929 potently blocks collagen-in...

Full description

Saved in:
Bibliographic Details
Published in:ACS Med Chem Lett
Main Authors: Jeffries, Daniel E., Borza, Corina M., Blobaum, Anna L., Pozzi, Ambra, Lindsley, Craig W.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2019
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956352/
https://ncbi.nlm.nih.gov/pubmed/31938459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00382
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items