PACAP27 mitigates an age‐dependent hippocampal vulnerability to PGJ2‐induced spatial learning deficits and neuroinflammation in mice

BACKGROUND: Inflammation in the brain is mediated by the cyclooxygenase pathway, which leads to the production of prostaglandins. Prostaglandin (PG) D2, the most abundant PG in the brain, increases under pathological conditions and is spontaneously metabolized to PGJ2. PGJ2 is highly neurotoxic, wit...

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Detalhes bibliográficos
Publicado no:Brain Behav
Main Authors: Avila, Jorge A., Kiprowska, Magdalena, Jean‐Louis, Teneka, Rockwell, Patricia, Figueiredo‐Pereira, Maria E., Serrano, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6955932/
https://ncbi.nlm.nih.gov/pubmed/31769222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/brb3.1465
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