Regulation of INF2-mediated actin polymerization through site-specific lysine acetylation of actin itself

INF2 is a formin protein that accelerates actin polymerization. A common mechanism for formin regulation is autoinhibition, through interaction between the N-terminal diaphanous inhibitory domain (DID) and C-terminal diaphanous autoregulatory domain (DAD). We recently showed that INF2 uses a variant...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: A, Mu, Fung, Tak Shun, Francomacaro, Lisa M., Huynh, Thao, Kotila, Tommi, Svindrych, Zdenek, Higgs, Henry N.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6955303/
https://ncbi.nlm.nih.gov/pubmed/31871199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914072117
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