High-depth whole genome sequencing of an Ashekenazi Jewish reference panel: Enhancing sensitivity, accuracy, and imputation

While increasingly large reference panels for genome-wide imputation have been recently made available, the degree to which imputation accuracy can be enhanced by population-specific reference panels remains an open question. Here, we sequenced at full-depth (≥30x), across two platforms (Illumina X...

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Veröffentlicht in:Hum Genet
Hauptverfasser: Lencz, Todd, Yu, Jin, Palmer, Cameron, Carmi, Shai, Ben-Avraham, Danny, Barzilai, Nir, Bressman, Susan, Darvasi, Ariel, Cho, Judy H., Clark, Lorraine N., Gümüş, Zeynep H., Joseph, Vijai, Klein, Robert, Lipkin, Steven, Offit, Kenneth, Ostrer, Harry, Ozelius, Laurie J., Peter, Inga, Atzmon, Gil, Pe’er, Itsik
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954822/
https://ncbi.nlm.nih.gov/pubmed/29705978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-018-1886-z
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